September 20, 2020 Journal article Open Access

Biruk Beletew Abate; Ayelign Mengesha Kasie; Melese Abate Reta; Mesfin Wudu Kassaw

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  <identifier identifierType="URL">https://nadre.ethernet.edu.et/record/8458</identifier>
  <creators>
    <creator>
      <creatorName>Biruk Beletew Abate</creatorName>
    </creator>
    <creator>
      <creatorName>Ayelign Mengesha Kasie</creatorName>
    </creator>
    <creator>
      <creatorName>Melese Abate Reta</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-1301-4746</nameIdentifier>
    </creator>
    <creator>
      <creatorName>Mesfin Wudu Kassaw</creatorName>
    </creator>
  </creators>
  <titles>
    <title>Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-09-20</date>
  </dates>
  <resourceType resourceTypeGeneral="JournalArticle"/>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://nadre.ethernet.edu.et/record/8458</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s00038-020-01489-x</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution-NonCommercial</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;&lt;strong&gt;Abstract&lt;br&gt;
Objectives&lt;/strong&gt; This systematic review and meta-analysis aimed to reveal the magnitude of neonatal sepsis and its associated&lt;br&gt;
factors in East Africa.&lt;br&gt;
&lt;strong&gt;Methods&lt;/strong&gt; Using PRISMA guideline, we reviewed and meta-analyzed studies from Google Scholar, Cochrane library, and&lt;br&gt;
PubMed; last search date: October 15, 2019. Heterogeneity across the studies was estimated. The subgroup analysis was&lt;br&gt;
done. Publication bias was also assessed.&lt;br&gt;
&lt;strong&gt;Results &lt;/strong&gt;A total of 26 studies with 11,239 participants are included. The pooled prevalence of neonatal sepsis in East Africa&lt;br&gt;
was 29.765% (95% CI 23.36&amp;ndash;35.94). Home delivery (AOR = 2.67; 95% CI 1.15&amp;ndash;4.00), maternal history of urinary tract&lt;br&gt;
infection (UTI) (AOR = 2.083; 95% CI 0.24&amp;ndash;3.93), gestational age/(preterm) (AOR = 1.56; 95% CI 1.04&amp;ndash;2.08), prolonged&lt;br&gt;
labor (AOR = 3.23; 95% CI 0.04&amp;ndash;6.51) and PROM (AOR = 1.95; 95% CI 0.53&amp;ndash;3.37) were identified associated factors of&lt;br&gt;
neonatal sepsis.&lt;br&gt;
&lt;strong&gt;Conclusions&lt;/strong&gt; The prevalence of neonatal sepsis in East Africa remains high. The relevant stockholders should give attention&lt;br&gt;
for neonates delivered from women with intranatal fever to prevent neonatal sepsis. Pregnant women should be screened&lt;br&gt;
for UTI. Appropriate interventions should be put in place to manage PROM to decrease the chance of ascending&lt;br&gt;
microorganisms.&lt;/p&gt;</description>
  </descriptions>
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