September 20, 2020 Journal article Open Access

Biruk Beletew Abate; Ayelign Mengesha Kasie; Melese Abate Reta; Mesfin Wudu Kassaw

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{
  "DOI": "10.1007/s00038-020-01489-x", 
  "author": [
    {
      "family": "Biruk Beletew Abate"
    }, 
    {
      "family": "Ayelign Mengesha Kasie"
    }, 
    {
      "family": "Melese Abate Reta"
    }, 
    {
      "family": "Mesfin Wudu Kassaw"
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2020, 
        9, 
        20
      ]
    ]
  }, 
  "abstract": "<p><strong>Abstract<br>\nObjectives</strong> This systematic review and meta-analysis aimed to reveal the magnitude of neonatal sepsis and its associated<br>\nfactors in East Africa.<br>\n<strong>Methods</strong> Using PRISMA guideline, we reviewed and meta-analyzed studies from Google Scholar, Cochrane library, and<br>\nPubMed; last search date: October 15, 2019. Heterogeneity across the studies was estimated. The subgroup analysis was<br>\ndone. Publication bias was also assessed.<br>\n<strong>Results </strong>A total of 26 studies with 11,239 participants are included. The pooled prevalence of neonatal sepsis in East Africa<br>\nwas 29.765% (95% CI 23.36&ndash;35.94). Home delivery (AOR = 2.67; 95% CI 1.15&ndash;4.00), maternal history of urinary tract<br>\ninfection (UTI) (AOR = 2.083; 95% CI 0.24&ndash;3.93), gestational age/(preterm) (AOR = 1.56; 95% CI 1.04&ndash;2.08), prolonged<br>\nlabor (AOR = 3.23; 95% CI 0.04&ndash;6.51) and PROM (AOR = 1.95; 95% CI 0.53&ndash;3.37) were identified associated factors of<br>\nneonatal sepsis.<br>\n<strong>Conclusions</strong> The prevalence of neonatal sepsis in East Africa remains high. The relevant stockholders should give attention<br>\nfor neonates delivered from women with intranatal fever to prevent neonatal sepsis. Pregnant women should be screened<br>\nfor UTI. Appropriate interventions should be put in place to manage PROM to decrease the chance of ascending<br>\nmicroorganisms.</p>", 
  "title": "Neonatal sepsis and its associated factors in East Africa: a systematic review and meta-analysis", 
  "type": "article-journal", 
  "id": "8458"
}