May 30, 2019 Journal article Open Access

Tesfaye Aychew Legesse; Melese Abate Reta

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{
  "DOI": "10.4314/ejhs.v29i3.2", 
  "author": [
    {
      "family": "Tesfaye Aychew Legesse"
    }, 
    {
      "family": "Melese Abate Reta"
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2019, 
        5, 
        30
      ]
    ]
  }, 
  "abstract": "<p><strong>ABSTRACT<br>\nBACKGROUND:</strong> Adherence is the most important factor in&nbsp;determining Antiretroviral Therapy (ART) treatment success and&nbsp;long-term viral suppression. Nonadherence to ART led to the&nbsp;human Immunodeficiency Virus (HIV) related morbidity and&nbsp;mortality. Moreover, it intensifies the risk of the emerging drug-resistant&nbsp;HIV strains. This study aimed to assess the level of ART&nbsp;adherence and to identify its predictive associated factors among&nbsp;people living with HIV/AIDS in Hara Town and its surroundings,&nbsp;North-Eastern Ethiopia.<br>\n<strong>METHODS: </strong>An institutional facility-based cross-sectional study&nbsp;was conducted from April to May 2017. A total of 454 individuals&nbsp;were on ART follow-up in the selected ART clinic, and only 418&nbsp;patients were recruited. Bivariate and multivariate logistic&nbsp;regression analyses were carried out to identify associated factors.&nbsp;Odds ratio and 95% Confidence Interval (CI) were calculated to&nbsp;determine the level of significance.&nbsp;</p>\n\n<p><strong>RESULTS: </strong>The level of ART adherence in the study setting was 300 (71.8%). Participants who had not disclosed their HIV status to<br>\ntheir families were 88% less likely to adhere to their ART&nbsp;medication than those who had disclosed their HIV status (Odds<br>\nratio (OR): 0.12, 95%CI:0.05-0.58; p&lt;0.001). On the other hand,&nbsp;participants who had not encountered drug side effects were<br>\n2.69 times more likely to adhere to their ART medication than&nbsp;those who had ever encountered drug side effects (OR: 2.69,<br>\n95%CI:1.27-5.05; p&lt;0.001).<br>\n<strong>CONCLUSION: </strong>A very low level of ART adherence was shown in&nbsp;the study population. It was below the recommended good&nbsp;adherence standard. Therefore, patients should get adequate and&nbsp;comprehensive ART adherence counselling before initiation of ART&nbsp;treatment and during the follow-up time.</p>", 
  "title": "Adherence to Antiretroviral Therapy and Associated Factors among People Living with HIV/AIDS in Hara Town and Its Surroundings, North-Eastern Ethiopia", 
  "type": "article-journal", 
  "id": "8651"
}