January 30, 2025 Thesis Open Access

Getachew, Meseret

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  <identifier identifierType="DOI">10.20372/nadre:8324</identifier>
  <creators>
    <creator>
      <creatorName>Getachew, Meseret</creatorName>
      <givenName>Meseret</givenName>
      <familyName>Getachew</familyName>
    </creator>
  </creators>
  <titles>
    <title>Prevalence of Delayed Antiretroviral Therapy Initiation and Its Associated Factors Among HIV-Infected Children at Dessie and Kombolcha Town Selected Public Health Facilities, South Wollo Zone, Amhara Region, Ethiopia</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2025</publicationYear>
  <dates>
    <date dateType="Issued">2025-01-30</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Thesis</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://nadre.ethernet.edu.et/record/8324</alternateIdentifier>
  </alternateIdentifiers>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsVersionOf">10.20372/nadre:8323</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://nadre.ethernet.edu.et/communities/wu</relatedIdentifier>
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  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
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  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;&lt;strong&gt;ABSTRACT&lt;br&gt;
Introduction: &lt;/strong&gt;Antiretroviral therapy has dramatically reduced human immunodeficiency virus related morbidity and mortality among HIV-infected individuals. One of the major HIV related challenges around the world is the significant percentage of people living with HIV start therapy at delayed stage despite of the availability of ART, which has negative impacts on the quality of life and more transmission of HIV infection.&lt;br&gt;
&lt;strong&gt;Objective:&lt;/strong&gt; Assessing the prevalence of delayed ART initiation and associated factors among HIV-infected children at Dessie and Kombolcha selected public health facilities Ethiopia, 2025.&lt;br&gt;
&lt;strong&gt;Method: &lt;/strong&gt;A facility-based Cross-sectional study design was conducted from August15 to October 30 2024 at Dessie and Kombolcha town-selected public health facilities. The sample size for this study was 422. Data was collected through an interviewer-administered pre-tested questionnaire and the collected data was entered into EPI-data 4.7.0 and analyzed using STATA 15 statistical software. Variables that had a p-value of &amp;le; 0.25 in bi-variable analysis were considered as candidates for multi-variable regression analysis. Adjusted Odds ratio along with 95% confidence interval was estimated to measure the strength of association between dependent and predictor variables.&lt;br&gt;
&lt;strong&gt;Results: &lt;/strong&gt;The overall proportion of delayed ART initiation among children less than 15 was 44.2% (95% CI: 39.47 - 49.04%). The finding of the study indicated that the variables of rural residences [AOR = 2.44; 95% CI: (1.12, 5.32)], base line CD4+ &amp;ge; 350cells/mm3 [AOR = 20.09, 95% CI: (8.76, 46.04)], hemoglobin level at base line &amp;ge; 10 mg/dl [AOR = 18.42; 95% CI: (6.99, 48.56)], taking medication prior to ART initiation [AOR = 2.67; 95% CI: (1.19, 6.00)], and children with past OI [AOR = 2.36; 95% CI: (1.04, 5.36)] had increased the log odds of delayed ART initiation of HIV-infected children. However, the other variables such as baseline viral load &amp;ge; 1000 [AOR = 0.06; 95% CI: (0.02, 0.13)], child has primary caregiver [AOR = 0.35; 95% CI: (0.14, 0.87)], and household residence locate near to hospital [AOR = 0.33; 95% CI: (0.14, 0.74)] had decrease the log odds of delayed ART initiation of HIV-infected children.&lt;br&gt;
&lt;strong&gt;Conclusion and Recommendations: &lt;/strong&gt;Nearly half of the children were delayed ART initiation among children on ART follow up at Dessie and Kombolcha town public health facilities. The factor variables such as residence, child has primary caregiver, baseline CD4 count, hemoglobin level , baseline viral load, taking any medication before ART initiation, child have past OI at ART enrollment, and households residing locate near to hospital were predictors of delayed ART initiation of HIV-infected children. Health care workers better to focus on early HIV testing mechanisms and timely linkage to HIV care by advocating &amp;ldquo;Test-and-Treat&amp;rdquo; should be strengthened. The government better to encourage service availability of rural residence.&lt;br&gt;
The health facility ART clinic staffs to have strict monitoring and early initiation of ART on CLHIV.&lt;br&gt;
&lt;strong&gt;Keywords: &lt;/strong&gt;Delayed ART Initiation, HIV-Positive Children, Dessie-Kombolcha&lt;/p&gt;</description>
  </descriptions>
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