May 15, 2025 Journal article Open Access

BY: KIBIRE MOSISA(BSc)

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    <dct:title>FACTORSPREDICTINGTREATMENTOUTCOMEOFNEONATAL SEPSIS AMONGNEONATESADMITTEDTONEONATALINTENSIVE CAREUNITINHORROGUDURUWOLLEGAZONEPUBLIC HOSPITALS, WESTERNETHIOPIA,2024</dct:title>
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    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2025</dct:issued>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2025-05-15</dct:issued>
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    <dct:description>&lt;p&gt;Background: One of the main causes of newborn morbidity and mortality globally is neonatal sepsis(Tewabe et al., 2017). The prevalence of neonatal sepsis worldwide According to estimates of the global epidemiological burden of sepsis, between 1.3 and 3.9 million newborns are estimated to get sepsis each year, with a global fatality rate of between 400,000 and700,000(Sisay, 2022),(Stoll et al., 2020). Objective: The main aim of this study was to assess treatment outcome of neonatal sepsis and its predictors among neonates treated for sepsis in neonatal intensive care units at public hospitals in Horro Guduru Wollega Zone, Western Ethiopia 2024. Methods: An institutional-based retrospective cohort study was conducted among 326 neonatal sepsis admitted to the neonatal intensive care unit at public hospitals in Horro Guduru Wollega and data were collected from May 25, to July 15, 2024. The data were collected from charts of neonatal sepsis by systematic random sampling and entered into Epi-data 4.6, analysed using the SPSS version 25. A bivariable and multivariable logistic regression models were used to identify predictors of treatment outcome of neonatal sepsis. Variables at p-value &amp;le;0.25 in bivariable analysis were entered into multivariable analysis. An Adjusted Odds Ratio (AOR) with a 95% confidence interval as well as P-value of less than 0.05 was used tojudge statistical significance. Results: A total of 326 charts were retrieved and 317 of them included in the analysis with the response rate of 97.2%.The mean age of the study participants 6.33 &amp;plusmn; 6.04 days. The poor treatment outcome of neonatal sepsis was 29.3% (95% CI; 24.5-34.5%). The following factors were linked to poor treatment outcomes: Appearance, pulse, Grimace, Activity and Respiration score of less than 7 at 5 minutes (AOR=7.9, 95% CI; 3.5-17.9), late onset of sepsis (AOR=3.4, 95% CI; 1.22-7.5), bradycardia (AOR=1.31, 95% CI; 1.12-0.84), Small for Gestational Age (AOR=9.26, 95% CI; 2.09-40.9), and Large for Gestational Age (AOR=5.54, 95%CI;1.32-23.26). Conclusion: The study found both maternal and neonatal factors as possible independent risk factors to have a strong association with the risk of poor outcome of neonatal sepsis. Factors predicting these poor outcomes included the risk of infection during pregnancy, being smaller or larger than average for gestational age, lower APGAR scores, late onset of sepsis, and bradycardia&lt;/p&gt;</dct:description>
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