June 26, 2024 Journal article Open Access

Tegene Atamenta kitaw1*, Biruk Beletew Abate1, Gizachew Yilak1, Befkad Derese Tilahun1, Abebe Merchaw Faris1, Getachew Tesfaw Walle1 and Ribka Nigatu Haile1

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        <foaf:name>Tegene Atamenta kitaw1*, Biruk Beletew Abate1, Gizachew Yilak1, Befkad Derese Tilahun1, Abebe Merchaw Faris1, Getachew Tesfaw Walle1 and Ribka Nigatu Haile1</foaf:name>
        <foaf:givenName>Biruk Beletew Abate1, Gizachew Yilak1, Befkad Derese Tilahun1, Abebe Merchaw Faris1, Getachew Tesfaw Walle1 and Ribka Nigatu Haile1</foaf:givenName>
        <foaf:familyName>Tegene Atamenta kitaw1*</foaf:familyName>
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            <foaf:name>1Department of Nursing, College of Health Science, Woldia University, Woldia, Ethiopia</foaf:name>
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    <dct:title>Virological outcomes of third-line antiretroviral therapy in a global context: a systematic reviews and meta-analysis</dct:title>
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        <foaf:name>Zenodo</foaf:name>
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    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2024</dct:issued>
    <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2024-06-26</dct:issued>
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    <dct:description>&lt;p&gt;Abstract&lt;br&gt; Background Despite remarkable progress, HIV&amp;rsquo;s influence on global health remains firm, demanding continued&lt;br&gt; attention. Understanding the effectiveness of third-line antiretroviral therapy in individuals who do not respond to&lt;br&gt; second-line drugs is crucial for improving treatment strategies. The virological outcomes of third-line antiretroviral&lt;br&gt; therapy vary from study to study, highlighting the need for robust global estimates.&lt;br&gt; Methods A comprehensive search of databases including PubMed, MEDLINE, International Scientific Indexing, Web&lt;br&gt; of Science, and Google Scholar, was conducted. STATA version 17 statistical software was used for analysis. A randomeffects model was applied to compute the pooled estimates. Subgroup analysis, heterogeneity, publication bias, and&lt;br&gt; sensitivity analysis were also performed. The prediction interval is computed to estimate the interval in which a future&lt;br&gt; study will fall. The GRADE tool was also used to determine the quality of the evidence.&lt;br&gt; Results In this systematic review and meta-analysis, 15 studies involving 1768 HIV patients receiving third-line&lt;br&gt; antiretroviral therapy were included. The pooled viral suppression of third-line antiretroviral therapy was 76.6% (95%&lt;br&gt; CI: 71.5- 81.7%). The viral suppression rates at 6 and 12 months were 75.5% and 78.6%, respectively. Furthermore,&lt;br&gt; third-line therapy effectively suppressed viral RNA copy numbers to &amp;le; 50 copies/mL, &amp;le; 200 copies/mL, and &amp;le; 400&lt;br&gt; copies/mL with rates of 70.7%, 85.4%, and 85.7%, respectively.&lt;br&gt; Conclusion More than three-fourths of patients on third-line antiretroviral therapy achieve viral suppression.&lt;br&gt; Consequently, improving access to and timely initiation of third-line therapy may positively impact the quality of life&lt;br&gt; for those with second-line treatment failure.&lt;br&gt; Key Summary Points&lt;br&gt; &amp;bull; Understanding the effectiveness of third-line antiretroviral therapy in individuals who do not respond to secondline drugs is crucial for improving treatment strategies.&lt;br&gt; &amp;bull; Currently, second-line treatment failure has been increasing, making progression to third-line therapy seemingly&lt;br&gt; mandatory in many settings, making it apparent that recent evidence is crucial.&lt;br&gt; &amp;bull; Viral suppression rate of third-line ART was 76.6% (95% CI: 71.5- 81.7%)&lt;br&gt; &amp;nbsp;&lt;/p&gt;</dct:description>
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