March 21, 2021 Journal article Open Access

Ermias Sisay Chanie1*, Dejen Getanh Feleke1, Sintayehu Asnakew2, Fisha Alebel GebreEyesus3, Aragaw Tesfaw4, Wubet Alebachew Bayih5, Agimasie Tigabu6, Yared Asmare Anyalem7, Abraham Tsedalu Amare6, Demeke Mesfin Belay1, Fentaw Teshome Dagnaw4 and Biruk Beletew Abate8

JSON-LD (schema.org) Export

{
  "description": "<p>Abstract<br>\nBackground: Even though antiretroviral therapy access for HIV infected children increased dramatically, anemia<br>\nhave been continued as a challenge regardless of a cluster of differentiation (CD4) count and viral load. Hence, this<br>\nstudy aimed to assess the time to detection of anemia and its predictors among children living with HIV at Debre<br>\nTabor and university of Gondar compressive specialized hospital, 2020.<br>\nMethods: A retrospective follow-up study was conducted from January 2010 to December 2018. A total of 372<br>\nchildren under the age of 15 who had received ART were included in the study. Data were collected from<br>\nchildren&rsquo;s medical charts and ART registration logbook using a standard checklist. Besides, the data were entered<br>\ninto Epi data 4.2.2 and then exported to Stata 14.0 for further analysis. The Cox regression model, the variables<br>\nhaving P-value &le;.05 with 95% CIs in multivariable analysis were declared as statistically significant for anemia.<br>\nResult: The mean (&plusmn;SD) of follow-up periods were 56.6 &plusmn; 1.7 SD months. The overall median survival time free from<br>\nanemia was 137 months, and the incidence rate of anemia was 6.9 per 100 PYO (95% CI: 5.3, 7.8). Moreover, WHO<br>\nclinical staging of III/IV [AHR: 4.2, 95% CI: 1.80, 11.1], low CD4 count below threshold [AHR: 1.9, 95% CI: 1.09, 3.37],<br>\ncotrimoxazole preventive therapy non-users, and poor level of adherence [(AHR: 2.4, 95% CI: 1.20, 4.85] were the<br>\nmain predictors of the time to detection of anemia.<br>\nConclusion: The incidence rate of anemia in our retrospective cohort was high. The risk of anemia is present in<br>\nchildren living with HIV infection but the risk for anemia is increased based on (WHO clinical staging III and IV, CD4<br>\ncount below the threshold level, CPT non-users, and poor level of adherence). Since many of these risk factors are<br>\npresent routinely, even within one single patient, our clinical monitoring for anemia quarterly was fully justified as<br>\nwas our routine switch from standard therapies such as AZT to another regimen upon lab confirmation of anemia.<br>\nAdditional methods to improve cotrimoxazole preventative therapy and level of adherence are also needed.<br>\n&nbsp;</p>", 
  "license": "http://www.opendefinition.org/licenses/odc-by", 
  "creator": [
    {
      "affiliation": "1Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. 2Department of Psychiatry, school of medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. 3Department of Nursing, College of Health Sciences, Wolkitie University, Wolkitie, Ethiopia. 4Department of Public health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. 5Department of Maternal and Neonatal Health Nursing College of Health Science, Debre Tabor University, Debre Tabor, Ethiopia. 6Department of Adult health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. 7Department of Pediatrics and Child Health Nursing, College of Health Sciences, Debre Birhan University, Debre Birhan, Ethiopia. 8Department of Nursing, College of Health Sciences, Woldia University, Woldia, Ethiopia.", 
      "@type": "Person", 
      "name": "Ermias Sisay Chanie1*, Dejen Getanh Feleke1, Sintayehu Asnakew2, Fisha Alebel GebreEyesus3, Aragaw Tesfaw4, Wubet Alebachew Bayih5, Agimasie Tigabu6, Yared Asmare Anyalem7, Abraham Tsedalu Amare6, Demeke Mesfin Belay1, Fentaw Teshome Dagnaw4 and Biruk Beletew Abate8"
    }
  ], 
  "headline": "Time to detection of anemia and its predictors among children living with HIV at Debre Tabor and University of Gondar Compressive Specialized Hospitals, 2020: a multicentre retrospective follow-up study.", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2021-03-21", 
  "url": "https://nadre.ethernet.edu.et/record/17232", 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.20372/nadre:17232", 
  "@id": "https://doi.org/10.20372/nadre:17232", 
  "@type": "ScholarlyArticle", 
  "name": "Time to detection of anemia and its predictors among children living with HIV at Debre Tabor and University of Gondar Compressive Specialized Hospitals, 2020: a multicentre retrospective follow-up study."
}