January 7, 2020 Thesis Open Access

ESMAEL AHMED

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{
  "inLanguage": {
    "alternateName": "eng", 
    "@type": "Language", 
    "name": "English"
  }, 
  "description": "<p>The use of plants for treatment of various diseases is universal and has been practiced for many years even up to now where many people are treated by modern drugs. Plants produce a wide variety of secondary metabolites which are used either directly as precursors or as lead compounds in the pharmaceutical industry.Numerous studies have aimed to describe the chemical composition of these plants&rsquo; antibacterial and the mechanisms involved in bacterial growth inhibition either separately or associated with conventional antibacterialmechanisms.In the present study, berries of Juniperus procera, Olea europeae subsp. cuspidata and Podocarpus falcatus were extracted by using different solvents such as methanol, petroleum ether, ethanol, chloroform and hexane.The solvent extracts were evaluated against six human pathogenic bacterial strains by usingagar well diffusion and agar dilution method (for MIC) assay methodswere employed. The test pathogenic organisms such as E. coli, S. typhi, S. dysenteriae, P. aerugenosa, S.aureus and K.pneumonia and were used.Among the solvents used to extract the biologically active substances from three medicinal plants, methanol was the best solvents followed by ethanol,chloroform, petroleum ether and hexane. The highest antibacterial activity was exhibited by methanol extract of Olea europeaeagainst S. dysentriae (18.33 &plusmn; 0.57mm) and the lowest againstK.pneumonia (10.66 &plusmn; 1.52mm) by hexane extract.The highestzone of inhibitionby methanol and ethanolextract ofPodocarpus falcatusagainstE. coli andS.aureus(16.33 &plusmn; 1.52mm)and the lowestagainst K. pneumonia (9.0 &plusmn; 1.0mm) by hexaneextractandthe highestzone of inhibitionbyethanolextract of Juniperus proceraagainstS. typhi(14.66 &plusmn; 1.52mm) and the lowestagainst K.pneumonia (3.0 &plusmn; 1.0mm) by petroleum ether;The lowesttMIC of crude extract ofOlea europeae,Podocarpus falcatus andJuniperus procera wereexhibited againstS.aureus,E.coli and S. dysentriae at the concentration of 1.56 mg/ml 3.13 mg/ml and 6.25 mg/ml bymethanol andethanolextract.Two dissimilar antibiotics such as ciprofloxacin and gentamicin were used as standard for testing antibacterial activity against six different human pathogens. The indicated the presence of some secondary metabolites existed in the tested pathogens which have related with antibacterial activities. The extracts of all Olea europeae plant should be translated into clinical practice.<br>\n3</p>", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "creator": [
    {
      "affiliation": "MADDA WALABU UNIVERSITY", 
      "@type": "Person", 
      "name": "ESMAEL AHMED"
    }
  ], 
  "headline": "ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF BERRIES OF Juniperus procera, Olea europeae AND Podocarpus falcatus COLLECTED FROM ADABA-DODOLAFOREST AGAINST SELECTED HUMAN BACTERIAL PATHOGENS", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2020-01-07", 
  "url": "https://nadre.ethernet.edu.et/record/11751", 
  "keywords": [
    "Antibacterial activity, berries, human pathogens, medicinal plants, solvents extraction"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.20372/nadre:11751", 
  "@id": "https://doi.org/10.20372/nadre:11751", 
  "@type": "ScholarlyArticle", 
  "name": "ANTIBACTERIAL ACTIVITIES OF EXTRACTS OF BERRIES OF Juniperus procera, Olea europeae AND Podocarpus falcatus COLLECTED FROM ADABA-DODOLAFOREST AGAINST SELECTED HUMAN BACTERIAL PATHOGENS"
}